Mechanism of alternative splicing and its application in diagnosis and treatment of leukemia / 中华检验医学杂志
Chinese Journal of Laboratory Medicine
;
(12): 730-732, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-483288
ABSTRACT
Alternative splicing is a process refering a pre-mRNA transforms to different mature mRNAs by different splicing sites combination, and then the mRNAs translate to various proteins.This process is regulated by a variety of cis acting elements and trans acting factors.Recent studies have shown that aberrant alternative splicing is prevalent in leukemia patients, and is closely associated with leukemic occurrence, development and chemotherapy resistance.This shows us that aberrant altemative splicing may be helpful to leukemia diagnosis and treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Chinese Journal of Laboratory Medicine
Ano de publicação:
2015
Tipo de documento:
Artigo
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