Prognostic Value of Soluble ST2 During Hospitalization for ST-Segment Elevation Myocardial Infarction
Annals of Laboratory Medicine
;
: 313-319, 2016.
Artigo
em Inglês
| WPRIM
| ID: wpr-48340
ABSTRACT
BACKGROUND:
Studying the role of soluble ST2 (sST2) during hospitalization for myocardial infarction (MI) can be helpful for predicting the course of the hospitalization and development of complications.METHODS:
We included 88 patients with MI (median age, 58 yr). Depending on the course of the hospitalization, the patients were divided into two groups the favorable (n=58) and unfavorable (n=30) outcome groups. On days 1 and 12 after MI, serum sST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured by ELISA.RESULTS:
On day 1, the concentrations of sST2 and NT-proBNP increased 2.4- and 4.5-fold, compared with the controls. Measurements on day 12 showed a significant decrease in the sST2 level (P=0.001), whereas the NT-proBNP level did not change. On day 1, the sST2 level in the unfavorable outcome group was 2-fold higher than that in the favorable outcome group and 3.7-fold higher than in the controls. On day 12, the marker level decreased in both groups. On day 1, the NT-proBNP level in the unfavorable outcome group was 6.8-fold higher than in the controls and 1.8-fold higher than in the favorable outcome group. On day 12, the level of NT-proBNP remained elevated in both groups. Determining the levels of both sST2 and NT-proBNP increases their diagnostic significance (odds ratio [OR], 1.92; 95% confidence interval [CI], 1.7-3.2; areas under curve [AUC] 0.89; P=0.004).CONCLUSIONS:
The level of sST2 is a more sensitive indicator during MI hospitalization than NT-proBNP.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fragmentos de Peptídeos
/
Prognóstico
/
Ensaio de Imunoadsorção Enzimática
/
Estudos de Casos e Controles
/
Modelos Logísticos
/
Razão de Chances
/
Modelos de Riscos Proporcionais
/
Curva ROC
/
Receptores de Somatostatina
/
Área Sob a Curva
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Annals of Laboratory Medicine
Ano de publicação:
2016
Tipo de documento:
Artigo
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