Early diagnosis and etiological analysis of 83 cases of neonatal purulent meningitis / 中国基层医药

ABSTRACT

Objective To Discuss early clinical manifestation and early antibiotic selection of neonatal puru-lent meningitis.Methods 83 cases diagnosed as neonatal purulent meningitis in the newborn were choosed as the research object.Retrospective analysis was used.Clinical data according to the complaints of the neonatal hospitalized were collected and analyzed to understand neonatal purulent meningitis early features,and to choose the effective anti-biotics under the undefined etiology circumstances in early stage.Results The early features was fever (51.8%), following with hyper -bilirubinemia of newborn(26.5%),livor(9.6%)and rhinostegnosis(9.6%).Microbiological examinationall cases with Blood cultures and CSF cultures,the result showed pathogenic bacteria testing positive were 15 cases(18.1%),blood culture positive were 11 cases(13.3%).Epidermis staphylococcus aureus was in the lead, followed by E.coli.And CSF cultures positive had only 4 cases(4.8%),E.Coli was in the majority.Etiology clear choosed sensitive antibiotic treatment among the 83 cases.Etiology unknown cases choosed penicillin and ceftriaxone sodium combined treatment for 2 weeks.Treatment effective was 72.3%,not cured or automatic discharge accounted for 27.7%.Conclusion Lumbar puncture should be used timely,in order to avoid missed diagnosis.Early use of penicillin combined ceftriaxone sodium treatment has better effect,and is worth popularizing in the grassroots.