Gut hormones in obesity and diabetes / 中国糖尿病杂志

ABSTRACT

[Summary] Pathophysiological mechanisms of obesity and type 2 diabetes is complex . In recent years ,data has showed that guthormone in obesity and T 2DM patients has changed ,and guthormones such as GLP-1 ,GIP ,PYY ,CCK and ghrelin are strongly related to the development of obesity and diabetes , resulting in a series of metabolic disorders ,this may be one of causes of the development of obesity and T2DM. In recent years ,the guthormone-based treatments or therapies associated with guthormone have became one of the hot topics in the diabetes research. Currently ,some guthormone-based treatment shave been used in clinical treatment of diabetes. This paper is a literature review on the history of gut hormones ,and how it affect the development of diabetes and obesity ,as well as aspects of clinical practice.