Effect of Yatongning tincture root canal implantation on IL-8,CD4 and HSP70 levels in gingival crevicular fluid of patients with periodontitis / 中国生化药物杂志

ABSTRACT

Objective To explore the effect of Yatongning tincture root canal implantation on interleukin 8 ( IL-8 ) , cluster of differentiation 4 (CD4) and heat shock protein 70(HSP70) in in gingival crevicular fluid of patients with periodontitis.Methods 64 patients with periodontitis from December 2013 to September 2015 in stomatology department of Yuyao Second People’s Hospital were selected and according to the different treatment methods divided into treatment group and control group, 33 cases in treatment group, 31 cases in control group.Patients received root canal implantation in two groups, the treatment group received Yatongning tincture root canal implantation on the basis of control group.The clinical curative effect, incidence of pain, IL-8, CD4 and HSP70 levels were compared between two groups.Results The clinical curative effect of treatment group was 96.97%(32 cases), which was higher than 80.65% (31 cases) of control group (χ2 =4.373, P<0.05).The pain incidence of treatment group was 30.30%(10 cases), which was higher than 58.06% (18 cases) of control group (χ2 =5.006,P<0.05).After treatment, the IL -8 levels were higher and CD4, HSP70 levels were lower in two groups than those pre-treatment(P<0.05), compared with control group, the IL-8 levels were higher and CD4, HSP70 levels were lower in treatment group ( P<0.05 ) .Conclusion Yatongning tincture root canal implantation could enhance the clinical efficacy , relieve tooth tissue damage and improve the post-operative pain in patients.