Effect of Shenmai injection combined with noninvasive ventilator on MDA, SOD and clinical efficacy in treatment of elderly patients with chronic respiratory failure / 中国生化药物杂志

ABSTRACT

Objective To investigate the effect of Shenmai injection combined with noninvasive ventilator on MDA , SOD and clinical efficacy in treatment of elderly patients with chronic respiratory failure.Methods 72 cases of elderly patients with chronic respiratory failure were randomly divided into control group and experimental group.Control group of 35 patients were treated with conventional therapy and the treatment of noninvasive ventilator, experimental group of 37 patients were treated combined with Shenmai injection for 1 weeks.The level of serum MDA, SOD and clinical efficacy were compared.Results The serum MDA level was decreased, SOD level increased in 2 groups after treatment (P<0.05), the level of MDA in experimental group was lower than control group, and the level of SOD was higher (P<0.05).The level of PaO2 was increased, PaCO2 level and QOL score decreased,the level of PaO2 in experimental group was higher than control group, the QOL score was lower than that of control group ( P<0.05),and there was no difference in PaCO2.After treatment, the total effective rate of experimental group was significantly higher than control group (P<0.05).Conclusion Shenmai injection combined noninvasive ventilator is effective on elderly patients with chronic respiratory failure, it can reduce serum MDA level, increase the serum SOD level.