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Association between Cognitive Subdomains and Extrapyramidal Signs in Alzheimer Disease: A Clinical Research Center for Dementia of South Korea (CREDOS) Study
Journal of Korean Geriatric Psychiatry ; : 20-25, 2013.
Artigo em Coreano | WPRIM | ID: wpr-48553
ABSTRACT

OBJECTIVES:

We aimed to investigate the prevalence of Extrapyramidal signs (EPS) and the associations between EPS and cognitive subdomains in patients with Alzheimer disease (AD).

METHODS:

We recruited 1,324 patients with AD from the Clinical Research of Dementia of South Korea (CREDOS), a hospital based cohort study with fifty-six participating hospitals. We estimated cognitive subdomain using the Seoul Neuropsychological Screening Battery-Dementia version (SNSB-D). Dementia severity was measured by Clinical Dementia Rating Sum of Boxes (CDR-SB) and Korean version of Mini-Mental Status Examination (K-MMSE). The EPS group was defined by the presence of at least one EPS based on a focused neurologic examination.

RESULTS:

The prevalence of patients with EPS was 11%. These had higher CDR-SB scores than non-EPS group. After controlling for demographic, radiological, and dementia severity (CDR-SB) factors, EPS group showed lower cognitive ability in the subdomains for visuospatial and frontal-executive function than non-EPS group. The patients with EPS were showed significantly higher scores in the subdomain for memory function.

CONCLUSION:

The presence of EPSs in patients with AD was associated with lower visuospatial, frontal-executive function and higher memory function.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Programas de Rastreamento / Prevalência / Estudos de Coortes / Manifestações Neurocomportamentais / Demência / República da Coreia / Doença de Alzheimer / Memória Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco / Estudo de rastreamento Limite: Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Journal of Korean Geriatric Psychiatry Ano de publicação: 2013 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Programas de Rastreamento / Prevalência / Estudos de Coortes / Manifestações Neurocomportamentais / Demência / República da Coreia / Doença de Alzheimer / Memória Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo de incidência / Estudo observacional / Estudo de prevalência / Estudo prognóstico / Fatores de risco / Estudo de rastreamento Limite: Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Journal of Korean Geriatric Psychiatry Ano de publicação: 2013 Tipo de documento: Artigo