Association between Cognitive Subdomains and Extrapyramidal Signs in Alzheimer Disease: A Clinical Research Center for Dementia of South Korea (CREDOS) Study
Journal of Korean Geriatric Psychiatry
;
: 20-25, 2013.
Artigo
em Coreano
| WPRIM
| ID: wpr-48553
ABSTRACT
OBJECTIVES:
We aimed to investigate the prevalence of Extrapyramidal signs (EPS) and the associations between EPS and cognitive subdomains in patients with Alzheimer disease (AD).METHODS:
We recruited 1,324 patients with AD from the Clinical Research of Dementia of South Korea (CREDOS), a hospital based cohort study with fifty-six participating hospitals. We estimated cognitive subdomain using the Seoul Neuropsychological Screening Battery-Dementia version (SNSB-D). Dementia severity was measured by Clinical Dementia Rating Sum of Boxes (CDR-SB) and Korean version of Mini-Mental Status Examination (K-MMSE). The EPS group was defined by the presence of at least one EPS based on a focused neurologic examination.RESULTS:
The prevalence of patients with EPS was 11%. These had higher CDR-SB scores than non-EPS group. After controlling for demographic, radiological, and dementia severity (CDR-SB) factors, EPS group showed lower cognitive ability in the subdomains for visuospatial and frontal-executive function than non-EPS group. The patients with EPS were showed significantly higher scores in the subdomain for memory function.CONCLUSION:
The presence of EPSs in patients with AD was associated with lower visuospatial, frontal-executive function and higher memory function.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Programas de Rastreamento
/
Prevalência
/
Estudos de Coortes
/
Manifestações Neurocomportamentais
/
Demência
/
República da Coreia
/
Doença de Alzheimer
/
Memória
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Journal of Korean Geriatric Psychiatry
Ano de publicação:
2013
Tipo de documento:
Artigo
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