Cigarette Smoke-Induced Interleukin-1 Alpha May Be Involved in the Pathogenesis of Adult Acne
Annals of Dermatology
;
: 11-16, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-48651
ABSTRACT
BACKGROUND:
Lipid peroxide (LPO) in comedones, which are produced as a result of sebum oxidation, might potentially induce interleukin-1alpha (IL-1alpha) and exacerbate comedogenesis and inflammatory changes in comedones.OBJECTIVE:
To investigate the relationship of proinflammatory cytokines and LPO levels in the extracts of comedones with the acne of clinical difference between smokers and non-smokers, and with the severity and distribution of the acne lesions.METHODS:
Twenty-two non-smoking and 21 smoking adult acne patients were evaluated by comedone extraction and measurement of proinflammatory cytokines and LPO levels. Acne severity and distribution of the lesions were also analyzed.RESULTS:
Relative to the non-smoking group, smokers had significantly higher levels of IL-1alpha and LPO in comedones. Their levels showed a positive correlation. However, there were no statistically significant difference between the severity or distribution of the disease and the levels of LPO and IL-1alpha in comedones.CONCLUSION:
Smoking may be involved in the pathogenesis of adult acne by increasing the oxidative stress that results in subsequent accumulation of LPO in comedones.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fumaça
/
Sebo
/
Fumar
/
Citocinas
/
Interleucina-1
/
Acne Vulgar
/
Estresse Oxidativo
/
Interleucina-1alfa
/
Produtos do Tabaco
Tipo de estudo:
Estudo de etiologia
Limite:
Adulto
/
Humanos
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2014
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS