Efficacy of reinforcing kidney and removing stasis combined with thalidomide in multiple myeloma / 中国生化药物杂志
Chinese Journal of Biochemical Pharmaceutics
;
(6): 111-114, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-486511
ABSTRACT
Objective To evaluate the efficacy of reinforcing kidney and removing stasis combined with thalidomide in the treatment of multiple myeloma.Methods 120 patients with multiple myeloma from January 2011 to January 2015 in department of traditional Chinese medicine of the third hospital affiliated to Liaoning medical university were divided into two groups.The control group received VAD program ( vincristine, doxorubicin and dexamethasone), and the observation group received reinforcing kidney and removing stasis combined with thalidomide on the basis of control group.All patients received treatment for four weeks of one course.Results After treatment, the total efficiency of observation group was higher than that of control group(75% vs.60%, P<0.05).Compared with control group, the M protein,plasmocyte count and osteoclasts count of observation group were lower, the osteoblast count of observation group was higher(P<0.05).The improvement rate of quality of life (KPS score) in observation group was higher than that in control group (70.00% vs.51.67%,P<0.05).The changes of renal function (serum creatinine, urea nitrogen) and adverse reaction in observation group were less than those in control group (P<0.05).Conclusion The reinforcing kidney and removing stasis combined with thalidomide has the significant effect in the treatment of multiple myeloma with fewer adverse reactions and higher quality of life after treatment.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Biochemical Pharmaceutics
Ano de publicação:
2016
Tipo de documento:
Artigo
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