Hyperbaric Oxygen Induced Autophagy in Neuropathic Rats / 中国医科大学学报

ABSTRACT

Objective To investigate whether hyperbaric oxygen(HBO)affected neuropathic pain through autophagy and verify the HBO effect. Methods A total of 60 male SD rats were selected for the study and randomly divided into 4 groupscontrol group(C group),sham operation group (S group),chronic constriction group(CCI group)and hyperbaric oxygen group(HBO group). LC3Ⅱand P62 were determined by Western blot method and the autophagy was detected by electron microscopy on the 7th day. Results CCI and HBO groups were significantly higher than C and S group in Western blot(P0.05). The expression of LC3Ⅱin HBO group was significantly higher than that in CCI group(P0.05). Conclusion Hyperbaric oxygen therapy can induce autophagy for anti?neuropathic pain.