Observation on Cycling Stability Effect of Methoxamine at Low Dose in Cesarean Section / 中国药师

ABSTRACT

Objective:To investigate the cycling stability effect of methoxamine at low dose in cesarean section in order to find the optimal regimen for the prevention and treatment of hypotension during cesarean section. Methods:Totally 200 patients with scheduled cesarean section were selected and randomly divided into the experimental group and the control group with 100 ones in each. The ex-perimental group was anesthetized through L3-4 lumbar-peridural puncture immediately followed by the infusion of methoxamine, and the control group was anesthetized in the same way, and only when the blood pressure was dropped by more than 15%, the infusion of me-thoxamine was given immediately (2-3mg diluted to 20ml). The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate ( HR) were compared between the two groups at five time points of before spinal anesthesia ( T0 ) , 5 min after spinal anesthe-sia ( T1 ) , 10 min after spinal anesthesia ( T2 ) , 15 min after spinal anesthesia ( T3 ) and the end of the operation ( T4 ) . The umbilical arterial blood gas and the 1-minute Apgar score of the newborn were recorded, and the adverse reactions in the two groups were com-pared. Results:In T1-T3, SBP and DBP in the two groups were significantly lower than those at T0(P0.05), and HR in the control group was significantly lower than that in the experimental group in T1-T3(P0. 05). The incidence of adverse reactions in the experimental group was significantly lower than that in the control group (P<0. 05). Conclusion: The prophylactic use of methoxamine through micro pump can maintain the cycling stability of cesarean section with higher reliability and without adverse effects on the newborn.