Research advances in selective adaptor protein autophagy of p62/sequestosome-1 / 中国药理学与毒理学杂志

ABSTRACT

p62/sequestosome-1(SQSTM1)is an important selective autophagy adaptor protein, which contains six functional regionsubiquitin-binding domain,Keap1 interacting region,LC3 interaction region,tumor necrosis factor receptor-associated factor 6 binding domain,Phox and Bem1p and ZZ-type zinc finger domain. p62/SQSTM1 plays an important role in the removal of ubiquitin proteins. It also regulates the signaling pathway of nuclear factor erythroid 2 related factor 2-antioxidant respose element, NF-κB and the caspase-8 mediated apoptosis. The abnormal expression of p62/SQSTM 8 is closely related to neurodegenerative diseases (such as Huntington disease,Alzheimer disease,Parkinson disease),cancer,infective diseases,genetic diseases and chronic diseases. So far many researchers have shed light on the structure function and mechanism of p62/SQSTM1. This paper reviews the role of p62/SQSTM1 in the metabolism of proteins,the regulation of multiple signaling pathways and in the occurrence of diseases in order to provide a new theoretical basis for the treatment of autophagy targets.