The application value of four detection methods in clinical diagnosis of tuberculosis / 国际检验医学杂志

ABSTRACT

Objective To explore the clinical diagnostic value of four kinds of diagnostic methods ,including pulmonary tubercu‐losis ,including T‐cell‐based spot test for tuberculosis infection(T‐SPOT .TB) ,rapid culture test for Mycobacterium tuberculosis , combined detection of IgM and IgG antibodies in tuberculosis and sputum or bronchoalveolar lavage fluid smear .Methods A total of 516 cases of patients who were initially diagnosed with tuberculosis and without medication were collected from October 2014 to May 2015 in this hospital .T‐SPOT .TB ,rapid culture test for Mycobacterium tuberculosis ,combined detection of IgM and IgG anti‐bodies in tuberculosis and sputum or bronchoalveolar lavage fluid smear were performed in all patients .The sensitivity of these methods were calculated and compared .Results The sensitivity of T‐SPOT .TB(88 .76% ) was higher than that of rapid culture test for Mycobacterium tuberculosis(45 .74% ) ,combined detection of IgM and IgG antibodies in tuberculosis(72 .87% ) and sputum or bronchoalveolar lavage fluid smear(17 .25% ) ,all had statistically significant differences(P< 0 .01) .Conclusion T‐SPOT .TB might have significant application value for detecting Mycobacterium tuberculosis infection and assisting the diagnosis of tuberculo‐sis .Meanwhile ,combining with other detection methods could greatly improve the diagnostic rate and meet different clinical needs .