HCN and Kv4 channel in epilepsy / 国际儿科学杂志

ABSTRACT

Voltage-gated ion channels play an important role in cell's excitability.HCN is short for hyperpolarization-activated cyclic nucleotide-gated channels, and Kv4 family is the main ingredients of transient outward potassium current (IA) produced by hippocampal neuron, both of which belong to voltage-gated ion channels.HCN channel and its mediated Ih current could influence the resting potential of cell membrane, control the excitability of neurons, synaptic potential and synaptic transmission.They also participate in cardiac pacing and rhythmic activity of some neurons.IA is the main ingredients of outward potassium current in the early period of action potential repolarization, which mainly takes part in regulating the synaptic input and counterpropagation of action potential.Kv4 channel could reduce the excitability of neurons.Studies indicate that mutations of these two channels lead to epilepsy.This article focuses on the structure、 distribution and function of HCN and Kv4 in epilepsy.