Effects of insulin-like growth factor-1 at varied levels on pregnancy outcome in pregnancy maternal serum and cord serum of patients with PCOS / 实用医学杂志

ABSTRACT

Objective To detect the effect of insulin-like growth factor-1 (IGF-1) at varied levels in pregnancy maternal serum and cord serum of patients with the polycystic ovary syndrome (PCOS) on pregnancy outcomes, and explore whether IGF-1 could be used as a diagnostic marker for PCOS. Methods From January 2012 to December 2013, pregnancy maternal and cord serums were collected from 120 PCOS patients and 120 normal pregnant women in the Department of Obstetrics and Gynecology of our hospital. ELISA was used to detect the levels of IGF-1, and analyze the levels of IGF-1 in different pregnancy outcomes between normal pregnant women and PCOS patients. Results Compared with the control group, the levels of IGF-1 in pregnancy maternal and cord blood were increased significantly in patients with PCOS (P< 0.05). The incidence of stillbirth, premature delivery and macrosomia was significantly higher in PCOS patients. The levels of IGF-1 in pregnancy maternal and cord serum were significantly higher in all PCOS patients with adverse pregnancy outcomes compared with the control group (P < 0.05). Conclusion IGF-1 could be used as a risk prediction marker for pregnancy outcome in patients with PCOS.