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Cardiovascular involvement in Behcet's disease / 대한내과학회지
Korean Journal of Medicine ; : 542-551, 2003.
Artigo em Coreano | WPRIM | ID: wpr-48802
ABSTRACT

BACKGROUND:

Behcet's disease (BD) is a systemic disease of unknown cause, belonging to vasculitis pathologically. There are only few reports describing the frequency and clinical features of cardiovascular involvement in BD, even though the vascular lesions involving artery and large-sized vein has been reported to be important in prognosis. We performed a retrospective study to address the clinical features of Behcet's disease involving cardiovascular system.

METHODS:

We studied 155 patients with BD who fulfilled the international criteria. The frequency and clinical characteristics of cardiovascular involvement were studied retrospectively.

RESULTS:

Among 155 patients with BD, 27 patients (17.4%) have cardiovascular involvement. When they were compared with patients without cardiovascular lesions, male proportion was significantly higher (OR 5.541, 95% CI 2.033~15.105, p=0.001) and the age at onset was younger (OR 1.059, 95% CI 1.003~1.118, p=0.037). Nine patients (5.8%) had arterial lesions which included 10 cases of arterial aneurysm and 3 cases of arterial occlusion. Arterial aneurysm occurred at aorta (3 cases) and pulmonary artery (3 cases) most frequently. Arterial occlusion occurred at coronary artery, brachial artery and digital artery. There were 4 patients with cardiac valvular lesions which included aortic regurgitation (3 cases) and tricuspid stenosis (1 case). Nineteen patients (12.3%) had venous lesions. Among them deep vein thrombosis were 25 cases, and transverse sinus thrombosis was one case. When the patients with deep vein thrombosis were divided by the site of the lesion, the cases involving deep femoral and popliteal vein were the most frequent (6 patients respectively), which were followed by iliac vein, superficial femoral vein, and superior vena cava. When the patients were divided into arterial and venous involvement groups, they showed no significant differences in clinical features.

CONCLUSION:

In BD patients, the frequency of cardiovascular involvement was 17.4% of which that of deep vein thrombosis was the highest. Arterial aneurysm was the most frequent among arterial lesions. The patients with cardiovascular involvement had significantly higher male proportion and younger onset age than the patients without cardiovascular lesions.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aorta / Insuficiência da Valva Aórtica / Veia Poplítea / Artérias / Prognóstico / Artéria Pulmonar / Vasculite / Veias / Veia Cava Superior / Artéria Braquial Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 2003 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Aorta / Insuficiência da Valva Aórtica / Veia Poplítea / Artérias / Prognóstico / Artéria Pulmonar / Vasculite / Veias / Veia Cava Superior / Artéria Braquial Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Humanos / Masculino Idioma: Coreano Revista: Korean Journal of Medicine Ano de publicação: 2003 Tipo de documento: Artigo