The expression and clinical significance of matrix metalioproteinase-2 and matrix metalloproteinase-9 in cervical cancer / 中国综合临床

ABSTRACT

Objective To sdudy the expression and clinical significance of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in cervical cancer.Methods Fifty-seven cases patients with cervical cancer who were treated in Hexigten Banner Hospital of Chifeng from January 2008 to December 2013 were selected as the observation group,and 23 patients with uterine benign lesion parallel hysterectomy were diagonosed by pathological diagonosis and selected as the control group.The positive expressions of MMP-2 and MMP-9 were observed and compared between observation group and control group.The correlation of MMP-2 and MMP-9 with clinical patholo gical factors were analyzed in cervical cancer patients.Results The positive expression rate of MMP-2 in observation group was 73.7％(42/57),significantly higher than that in the control group (21.7％ (5/23),P =0.032).The positive expression rate of MMP-9 in observation group was 61.4％ (35/57),significantly higher than that in control group (26.1％ (6/23),P =0.046).There were no significant differences between the expression of MMP-2,MMP-9 with the patient's age,the tumor chnical staging,the pathological type,the degree of differentiation and the diameter of tumor(P＞0.05),while the positive expression of MMP-2 and MMP-9 in patients with lymph node metastasis was higher than that in patients without lymph node metastasis(P =0.048,0.031).There was positive correlation between the expression of MMP-2 and MMP-9 (r =0.89,P＜0.05).Conclusion The expression of MMP-2 and MMP-9 in cervical cancer is higher than that in benign lesion,and the positive expression of MMP-2 and MMP-9 in patients with lymph node metastasis is higher than that in patients without lymph node metastasis,which indicate that the expression of MMP-2 and MMP-9 may play an role in the occurrence and development of cervical cancer,and associate with the invasion and metastasis of cervical cancer.