Effects of hypoxia-inducible factor-1α on the expression of heat shock proteins 90, Caspase 3 and Caspase 9 after cerebral ischemia-reperfusion / 中华老年医学杂志
Chinese Journal of Geriatrics
;
(12): 334-337, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-488670
ABSTRACT
Hypoxia-inducible factor-1α (HIF-1α)is a transcription factor that acts as a master regulator of gene expression induced by low oxygen conditions.HIF-1α is the most sensitive indicator of hypoxia and can be activated by systemic hypoxia,cerebral hemisphere ischemia and cerebral focal ischemia.HIF-1 expression can be induced by hypoxic-ischemic damage after cerebral infarction and exert its effects on hypoxia-inducible downstream genes,thus protecting hypoxic tissues and cells under hypoxic conditions via regulating the expression of its downstream target genes.This article reviews the expression of HIF-1α and its downstream target genes in acute cerebral ischemia,in order to provide a theoretical basis for gene therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Geriatrics
Ano de publicação:
2016
Tipo de documento:
Artigo
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