Effects of ABO blood group factors on postoperative cognitive function in elderly patients / 中华麻醉学杂志

ABSTRACT

Objective To investigate the effects of ABO blood group factors on postoperative cognitive function in elderly patients.Methods One hundred twenty patients, aged 65-75 yr, with body mass index of 17-26 kg/m2, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ , scheduled for elective thoracic surgery, were divided into 4 groups (n =30 each) according to the blood group blood group A group (group A), blood group B group (group B), blood group O group (group O) and blood group AB group (group AB).Combined general-epidural anesthesia was used during surgery, patient-controlled epidural analgesia was performed after surgery, and visual analogue scale score was maintained ≤4.Before surgery (T0), and at 6, 24 and 72 h after surgery (T1-3), Mini-Mental State Examination (MMSE) was used to assess the cognitive function, and the occurrence of postoperative cognitive dysfunction (POCD) was recorded.Blood samples were drawn from the central vein at T0-3 for determination of neuron-specific enolase (NSE) and S-100β protein concentrations in serum.Results Compared with the values at T0, MMSE scores were significantly decreased, and serum NSE and S-100β concentrations were increased at T1-3 in A, B and AB groups, and at T1 and T2 in group O (P＜0.05).Compared with group A, MMSE scores were significantly increased, and serum NSE and S-100β concentrations were decreased at T1-3 in B, AB and O groups (P＜0.05).Compared with group O, MMSE scores were significantly decreased, and serum NSE and S-100β concentrations were increased at T1.3 in B and AB groups (P＜0.05).There was no significant difference in MMSE scores and serum NSE and S-100β concentrations at T1-3 between group B and group AB (P＞0.05).The incidence of POCD from the high to the low was group A, group AB, group B, and group O in turn (P＜0.05 or 0.01).Conclusion ABO blood group factors affect postoperative cognitive function in elderly patients, elderly patients of blood group A are found to be prone to develop POCD, and the incidence of POCD is relatively low for elderly patients of blood group O.