Risk factors of myasthenic crisis after thymectomy: a meta analysis / 中华胸心血管外科杂志
Chinese Journal of Thoracic and Cardiovascular Surgery
;
(12): 660-664, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-489014
ABSTRACT
Objective To evaluate the risk factors of myasthenic crisis after thymectomy for myasthenia gravis.Methods Meta-analysis was performed to screen risk factors of myasthenic crisis after thymectomy for myasthenia gravis based on 21 associated articles published and carried out using Stata12.0.Results Twenty one studies were identified, including 3 092 patients and 698 patients developed myasthenic crisis after thymectomy.Complicated with thymoma(OR =3.93, 95% CI 2.37-6.50, P =0.000), Ossermen classification (OR =0.12, 95 % CI 0.09-0.17 , P =0.000) , history of preoperative myasthenic crisis (OR =5.36, 95 % CI 3.82-7.51, P =0.000) , use steroid hormonea (OR =1.75,95 % CI 1.26-2.43, P =0.001) , postopertive lung infection(OR =4.27,95% CI 1.63-11.18, P =0.003) , operation methods(OR =0.34,95% CI 0.21-0.56, P =0.000) , the dose of preoperative anticholinesterase drags (OR =0.35, 95 % CI 0.18-0.66, P =0.000) ,pulmonary function(OR =0.18, 95% CI 0.06-0.57, P =0.004), preoperative serum level of anti-acetylcholine receptor antibody(OR =0.06, 95% CI0.03-0.13, P =0.000)were associated with myasthenic crisis after thymectomy.Gender, course of disease were not associated with myasthenic crisis after thymectomy.Conclusion With thymoma, Ossermen classification, history of preoperative myasthenic crisis, use steroid hormonea, operation methods, the high dose of preoperative anticholinesterase drugs, poor pulmonary function, postopertive lung infection, high preoperative serum level of anti-acetylcholine receptor antibody are risk factors affecting myasthenic crisis after thymectomy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
/
Revisões Sistemáticas Avaliadas
Idioma:
Chinês
Revista:
Chinese Journal of Thoracic and Cardiovascular Surgery
Ano de publicação:
2015
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS