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Nefopam Reduces Dysesthesia after Percutaneous Endoscopic Lumbar Discectomy
The Korean Journal of Pain ; : 40-47, 2016.
Artigo em Inglês | WPRIM | ID: wpr-48903
ABSTRACT

BACKGROUND:

Neuropathic pain, including paresthesia/dysesthesia in the lower extremities, always develops and remains for at least one month, to variable degrees, after percutaneous endoscopic lumbar discectomy (PELD). The recently discovered dual analgesic mechanisms of action, similar to those of antidepressants and anticonvulsants, enable nefopam (NFP) to treat neuropathic pain. This study was performed to determine whether NFP might reduce the neuropathic pain component of postoperative pain.

METHODS:

Eighty patients, who underwent PELD due to herniated nucleus pulposus (HNP) at L4-L5, were randomly divided into two equal groups, one receiving NFP (with a mixture of morphine and ketorolac) and the other normal saline (NS) with the same mixture. The number of bolus infusions and the infused volume for 3 days were compared in both groups. The adverse reactions (ADRs) in both groups were recorded and compared. The neuropathic pain symptom inventory (NPSI) score was compared in both groups on postoperative days 1, 3, 7, 30, 60, and 90.

RESULTS:

The mean attempted number of bolus infusions, and effective infused bolus volume for 3 days was lower in the NFP group for 3 days. The most commonly reported ADRs were nausea, dizziness, and somnolence, in order of frequency in the NFP group. The median NPSI score, and all 5 median sub-scores in the NFP group, were significantly lower than that of the NS group until postoperative day 30.

CONCLUSIONS:

NFP significantly reduced the neuropathic pain component, including paresthesia/dysesthesia until 1 month after PELD. The common ADRs were nausea, dizziness, somnolence, and ataxia.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Dor Pós-Operatória / Parestesia / Ataxia / Infusões Intravenosas / Discotomia Percutânea / Discotomia / Extremidade Inferior / Tontura / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Avaliação de Sintomas Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Pain Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Dor Pós-Operatória / Parestesia / Ataxia / Infusões Intravenosas / Discotomia Percutânea / Discotomia / Extremidade Inferior / Tontura / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos / Avaliação de Sintomas Limite: Humanos Idioma: Inglês Revista: The Korean Journal of Pain Ano de publicação: 2016 Tipo de documento: Artigo