Analysis of chromosome karyotypes in 80 patients with M2 subtype acute myeloid leukemia in Xinjiang Uygur Autonomous Region / 肿瘤研究与临床

ABSTRACT

Objective To explore the chromosome abnormality characteristics and ethnic differences in patients with M2 subtype acute myeloid leukemia (AML-M2) in Xinjiang Uygur Autonomous Region.Methods The chromosome karyotypes of 80 cases of AML-M2 were detected by using 24 hours short-term culture method and R banding technique.The chromosome abnormality characteristics and ethnic differences were analyzed.Results In 80 patients,48.75 ％ (39/80) patients had abnormal chromosome karyotype,with t(8;21) abnormaled in 48.71％ (19/39),including pure t(8;21) [15.38 ％ (6/39)] and t(8;21) with other chromosomal abnormalities [33.3 ％ (13/39)],witch majority with t(8;21) and lack of sex chromosome (-X or -Y) [23.08 ％ (9/39)].51.28 ％ (20/39) patients with the exception of t(8;21) chromosomal abnormalities.The differences of abnormal chromosome karyotype in Han and Uygur patients were statistically significant [62.50 ％ (25/40) vs 35.00 ％ (14/40),x2 =16.66,P ＜ 0.01].Conclusion The chromosome karyotype characteristics of Han and Uygur M2 patients exist differences.