Relation between macroscopic type and cellular origin of intrahepatic cholangiocarcinoma / 国际外科学杂志

ABSTRACT

Intrahepatic cholangiocarcinoma,which occurrence and development involved kinds of cells and genes changes,is a vital part of the primary carcinoma of liver.The cellular origin may includes bile duct epithelial cells,hepatic stem cells and hepatic cells.The macroscopic type may includesnass-forming types,periductal infiltrating types,intraductal growth types.The fact was revealed that different macroscopic type of intrahepatic cholangiocarcinoma has different clinical features,outcomes and prognosis.The author reviewed recently published studies covering various aspects of intrahepatic cholangiocarcinoma,focusing especially on the macroscopic subtypes and related cell features,to discover the relaticn between macroscopic type and cellular origin of intrahepatic cholangiocarcinoma and better understand the pathogenesis of intrahepatic cholangiocarcinoma.