Anti-cancer effect of metformin and regulation on HIF-1α / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 113-115, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-489671
ABSTRACT
Studies show that metformin inhibits the proliferation of several types of cancer cells.All evidences,therefore propose the anti-tumor effect of metformin.Metformin can repress the oxygen consumption of tumor cells,and suppress hypoxia-inducible factor-1α (HIF-1ct) accumulation through the translational and posttranslational mechanisms,and suppress the expression of HIF-1α by activating AMP-activated protein kinase (AMPK).
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Oncology
Ano de publicação:
2016
Tipo de documento:
Artigo
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