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Establishment of Aortic Regurgitation Model in Chinese Miniature Pigs Under Echocardiography Guidance / 中国循环杂志
Chinese Circulation Journal ; (12): 495-498, 2016.
Artigo em Chinês | WPRIM | ID: wpr-489983
ABSTRACT

Objective:

To establish the aortic regurgitation model in Chinese miniature pigs under echocardiography guidance.

Methods:

The animal models were established by following

steps:

general anesthesia, measuring body weight and then receiving echocardiography examination to exclude aortic valve lesions; carotid artery was exposured by surgery, catheter was sent to aortic sinus with stiff guide wire penetrates and the position of catheter was adjusted to obtain aortic valve damage. The aortic valve injury and regurgitation were evaluated by ultrasound; then the pigs were killed and the heart was taken to observe aortic valve damage.

Results:

A total of 7 pigs were used including 4 male and 3 female with the mean body weight of (24.7 ± 3.6) kg. Aortic regurgitation model was successfully established in 5 pigs including 1 mild, 1 mild-moderate, 2 moderate, 1 severe aortic valve regurgitation, and 4 were with valve lealfets perforation and 1 with lealfets tearing.

Conclusion:

Echocardiography can smoothly guide wire go through aortic valve and make valve damage at different degrees, it is reliable to establish aortic valve regurgitation model in experimental pigs.②Echocardiography may clearly identify the position and degree for aortic valve injury.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Guia de Prática Clínica Idioma: Chinês Revista: Chinese Circulation Journal Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Guia de Prática Clínica Idioma: Chinês Revista: Chinese Circulation Journal Ano de publicação: 2016 Tipo de documento: Artigo