Development of mesenchymal stem cell homing / 中国组织工程研究

ABSTRACT

BACKGROUND:As a kind of adult stem cel s with low immunogenicity, mesenchymal stem cel s are able to differentiate into different cel lineages in the treatment of many diseases. Moreover, mesenchymal stem cel s have been extensively used in many fields such as stem cel transplantation, immune therapy, and tissue engineering. OBJECTIVE:To review the progress of homing mechanism and the strategies to promote mesenchymal stem cel homing, thus providing a theoretical basis for transplanting mesenchymal stem cel s safely and efficiently. METHODS:The CNKI and PubMed databases were retrieved by computer for articles regarding mesenchymal stem cel homing published from 2000 to 2016, including reviews, basic and clinical studies. The key words were“mesenchymal stem cel s, homing”in Chinese and English, respectively. Then 74 papers were suitable for final analysis. RESULTS AND CONCLUSION:Mesenchymal stem cel homing needs further research, especial y the molecular mechanism of cel mobilization. Therefore, basic research about mesenchymal stem cel s should be further developed, and a standardized homing system should be established in vitro. In addition, it is of great significance to study the in vivo effects of transplanted gene-transfected mesenchymal stem cel s.