Clinical value of human kallikrein 2 detection on patients with prostate cancer / 国际检验医学杂志

ABSTRACT

Objective To study the clinical value of human kallikrein 2 detection on the early diagnosis ,prognosis and therapeu‐tic means of patients with prostate cancer .Methods 25 patients with prostate cancer and 25 patients with benign prostatic hyper‐plasia who were treated in affiliated hospital of Guangzhou Medical University between January 2015 and December 2015 were se‐lected as research objects .Their human kallikrein 2 and prostate specific antigen level were detected by ELISA and RIA .25 cases of prostatic cancer after operation of our hospital in synchronization were randomly selected as research objects and their human kal‐likrein 2 level was detected and analysed .All the data was modeling processed by SPSS21 .0 .Results Human kallikrein 2 level of PCa group ,BPH group and healthy group was(75 .5 ± 24 .5)ng/L ,(23 .3 ± 5 .8)ng/L and(22 .2 ± 3 .56)ng/L respectively ,which of PCa group was higher than that of BPH group and healthy group .The difference had statistical significance(P<0 .05) .The specific and accuracy of hK2 detecting PCa was 89% and 78% .Compared with before operation[(80 .2 ± 24 .5)ng/L] ,hK2 level of 25 pa‐tients with prostate cancer[(34 .4 ± 10 .5)ng/L] significantly decreased and the difference had statistical significance(P<0 .05) . Conclusion On diagnosing prostate cancer ,human kallikrein 2 can improve specific detection ,reduce unnecessary detected rate and provide the new direction for early clinical detection ,prognosis and therapy .It deserves further promotion .