The correlation between glucocorticoid and caries / 实用口腔医学杂志

ABSTRACT

Objective:To observe the changes of salivary Lysozyme (LZM),immunoglobulin A (IgA),lactate dehydrogenase (LDH),mean grey values (MGVs)of hard tissue of teeth and caries index(CSI)in patients after oral administration of glucocorticoid (GC).Methods:30 patients with oral administration of GC were included.The mixed saliva samples before and after 6 and 12 months of GC treatment were collected.LZMand IgA and LDH were examined.Surface layer panaorama films were taken and MGVs of hard tissue of teeth were measured.The decayed,missing and filled tooth(DMFT),decayed,missing and filled surface (DMFS), CSI were recorded.The same indexes were obtained from 30 age and gender matched healthy subjects as the control data.All statisti-cal analyses were performed using SPSS 17.0 software package.Results:After taking GC orally,the concentration of LZM,IgA and MGVs of hard tissue of teeth in the patients were lower than those in the controls(P <0.05),the LDH concentration,DMFT,DMFS and CSI in the patients were increased(P <0.05).In the patients the MGVs of hard tissue of teeth was negatively correlated with DM-FT,DMFS and CSI(P <0.01),LDH concentration was positively correlated with CSI(P <0.01),the concentration of LZMand IgA were negatively correlated with CSI(P <0.05).No change of the indexes was found in the controls.Conclusion:Oral administration of GC may increase DMFT,DMFS and CSI,decrease MGVs of hard tissue of teeth significantly reduce,the patients may be under higher risk of caries.