Clinical significance of homocysteine level detection before and after radiotherapy in patients with nasopharynx cancer / 国际检验医学杂志

ABSTRACT

Objective To investigate the clinical significance of detecting the homocysteine (Hcy) level by enzymatic cycling as‐say before and after radiotherapy in nasopharynx cancer .Methods 62 cases of definitely diagnosed nasopharynx cancer in our hos‐pital from September 2013 to September 2014 were included into the observation group and 60 individuals undergoing the physical examination were enrolled as the control group .The venous blood was collected once in the control group and was collected before radiotherapy and at 1 week ,1 month after the radiotherapy beginning in the observation group .The enzymatic cycling assay was used to test the Hcy level .Then the detection results were compared between the two groups .Results The Hcy level had no statis‐tically significantly difference among different stages of nasopharynx cancer before radiotherapy (F= 0 .15 ,P= 0 .86) .The Hcy level before radiotherapy and at 1 week after radiotherapy in the observation group were significantly higher than that in the control group ,the difference was statistically significant (t= - 12 .1 ,P< 0 .05 ;t= - 7 .32 ,P= 0 .00) .The Hcy level at 1 month after radio‐therapy in the observation group had no statistical difference compared with that in the control group (t= - 1 .45 ,P = 0 .15) .The Hcy level at 1 week and 1 month after radiotherapy in the observation group was significantly reduced ,which showed statistical difference compared with before radiotherapy (t= - 5 .22 ,P= 0 .00 ;t= - 13 .56 ,P= 0 .00) .Conclusion The Hcy level in the pa‐tients with nasopharynx cancer is significantly increased ,whereas with the conducting radiotherapy ,which shows the decreasing trend ,indicating that the Hcy level has certain guidance value for the diagnosis and treatment of nasopharynx cancer ,but the Hcy level has no obvious difference among different stages of nasopharynx cancer .