Relationship of neutrophils lymphocyte ratio and red blood cell distribution width with idiopathic facial palsy / 中国组织工程研究

ABSTRACT

BACKGROUND:Similarly with C-reactive protein, red blood cel distribution width can reflect the inflammatory process. Red blood cels involved in inflammatory process leads to the increase in red blood cel distribution width due to various inflammation factor receptors existingon the surface of red blood cel s. OBJECTIVE:To analyze the relationship between the neutrophils lymphocyte ratio, red blood cel distribution width and the pathogenesis andseverity of idiopathic facial paralysis. METHODS:The severity of idiopathic facial paralysis was assessed using the House and Brackmann Facial Nerve Grading System (HB) and Sunnybrook System (SB) in 30 included patients with idiopathic facial paralysis (disease group). The patients were graded as general (score 30-100) and severe paralysis (score 0-29) according to SB scores, or as mild (grade II/III), moderate (grade IV), severe paralysis (grade V/VI) according to HB grades. In addition, 30 healthy volunteers were selected as control group. Neutrophils lymphocyte ratio (NLR) and red blood cel distribution width (RDW) were compared between groups. The correlation of SB and HB scores with neutrophils lymphocyte ratio (NLR) and red blood cel distribution width was analyzed. RESULTS AND CONCLUSION:Neutrophils lymphocyte ratio was higher in the disease group than the control group (P< 0.01). A significant difference in red blood cel distribution width was found between different stages of disease severityin patients. Red blood cel distribution width was negatively correlated with SB scores (P< 0.01), while was positively correlated with HB grades (P< 0.01). Our results suggest that (1) neutrophils lymphocyte ratio is increased when idiopathic facial paralysis occurs; (2) red blood cel distribution widthis positively correlated with the severity of idiopathic facial paralysis, which indicates that inflammation is involved in the pathogenesis of idiopathic facial paralysis, and red blood cel distribution may be a marker for assessing the severity of idiopathic facial paralysis.