Relationship between gastric fundus gland polyps and Helicobacter pylori infection and acid inhibitor / 中国综合临床

ABSTRACT

Objective To investigate the relationship among infection of the gastric fundus gland polyps and Hp,and the use of proton pump inhibitors(PPI).Methods From January 2012 to January 2014,89 cases of gastric fundus gland polyps who were treated in the First Central Hospital of Baoding were selected as the observation group.Fifty cases of the same period for the examination of the superficial gastritis were selected as the control group.First,the occurrence of glandular polyps in the observation group was counted statistically,and then Hp infection,taking PPI,H2RA and gastric mucosal protective agent were compared with control group.Another 50 cases of gastric cancer patients were selected,then the Ki-67 antigen test was used for contrast analysis among the three groups.Results The occurrence proportion of undic gland polyps occurred in fundic,gastric body,cardiac and gastric antrum were 34.83％ (31/89),43.82％ (39/89),12.36％ (11/89) and 8.99％(8/89) respectively,the difference was significant (x2=5.192,P=0.001),and more in the form of a single appearance,accounting for 65.17％(58/89).The Hp infection rate of the observation group was 50.56％ (45/89),compared with 54.00％ (27/59) of control group,the difference was not statistically significant (x2=0.152,P=0.697),and the Hp infection intensity of observation group concentrated in the low and mild,while in the control group,the high intensity was the main.Ki-67 antigen test comparison showed that expression in the gastric cancer group was 82.00％ (41/50),significantly higher than that of the observation group(23.60％ (21/89)),the difference was statistically significant(x2=44.196,P=0.000).Conclusion Hp infection and long-term administration of PPI,H2RA,gastric mucosal protective agent are not the risk factors of gastric gland polyps.And the gastric fundus gland polyps are in the benign disease condition,do not have the deterioration tendency.