Effects of Vitamin and Antioxidant Supplements in Prevention of Bladder Cancer: a Meta-Analysis of Randomized Controlled Trials
Journal of Korean Medical Science
; : 628-635, 2017.
Article
em En
| WPRIM
| ID: wpr-49316
Biblioteca responsável:
WPRO
ABSTRACT
This study aimed to investigate the effects of vitamin and antioxidant supplements in the prevention of bladder cancer using a meta-analysis of randomized controlled trials (RCTs). Fourteen RCTs were included in the final analysis. In a fixed-effect meta-analysis, vitamin and antioxidant supplements showed no preventive effect for bladder cancer (relative risk [RR] = 1.04; 95% confidence interval [CI] 0.92–1.17; I² = 39.7%). Also, there was no preventive effect of these supplements in the subgroup meta-analyses by various factors such as type of supplements, type of cancer prevention, methodological quality, providers of supplements, type of control group, and number of participants. Among the subgroup analyses by type of supplements, beta-carotene supplementation alone marginally increased the risk of bladder cancer (RR = 1.44; 95% CI 1.00–2.09; I² = 0.0%; n = 3). The current meta-analysis found that vitamin and antioxidant supplements have no preventive effect against bladder cancer.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Systematic_reviews
Idioma:
En
Revista:
Journal of Korean Medical Science
Ano de publicação:
2017
Tipo de documento:
Article