Intraoperative intraperitoneal chemotherapy in radical surgery sustained impact on the prognosis of patients with gastric cancer / 中国综合临床

ABSTRACT

Objective o explore intraperitoneal human fluorine safe release chemotherapy after radical surgery on the prognosis of patients with gastric cancer.Methods One hundred gastric cancer patients who were treated in Jinshan Hospital Affiliated to Fudan University from June 2011 to September 2012 were selected and divided into observation groups (gastrectomy + Human fluorine An chemotherapy) and control group (simple gastrectomy) according to a random number table method.Biochemical index before treatment and 7 d after treatment,complication occurrence and survival rate of two groups were compared.Results There were no statistically significant differences in terms of WBC,PLT,IBIL,Cr and other biochemical markers before and after treatment between the two groups (P＞0.05).There were statistically significant differences in terms of chemical peritonitis,intestinal obstruction,fistula,intestinal perforation and other complications between two groups (P＞0.05).The 6 months,1 year,2-year survival rates of control group were 87.50％,80.00％,62.50％,of observation group were 96.67％,90.00％,78.33％,the differences were significant (x2 =6.108,8.796,4.579;P=0.014,0.003,0.032).The 6 months,1 year,2-year free survival rates of control group were 75.00％,55.00％,35.00％,of observation group were 93.33％,86.67％,70.00％,the differences were significant (x2 =3.902,6.635,5.203;P =0.045,0.010,0.021).Conclusion Intraoperative intraperitoneal chemotherapy sustained radical surgery in patients with no adverse effects on the stomach,can effectively improve the postoperative survival rates,worthy of promotion.