Identification of 17 Memory-enhancing Drugs Illegally Added in Traditional Chinese Medicines and Health Foods by LC-MS/MS / 中国药师

ABSTRACT

Objective:To develop an LC-MS/ MS method for the analysis of 17 memory-enhancing drugs illegally added in tradi-tional Chinese medicines(TCM)and health foods. Methods:The method involved liquid chromatography-tandem mass spectrometry (LC-MS/ MS),and the separation was conducted on an Eclipse XDB C18 column(100 mm × 3. 0 mm,1. 8 μm). The 17 memory-en-hancing drugs illegally added in traditional Chinese medicines and health foods were analyzed by LC-MS/ MS with electrospray ioniza-tion(ESI)and multiple reactions monitoring(MRM). Results:A fast LC-MS/ MS method for the simultaneous screening of 17 illegal-ly added chemical components was described with the LOD below 10 ng·ml - 1 . Conclusion:The method is selective and sensitive in the detection of memory-enhancing drugs illegally added in traditional Chinese medicines and health foods.