Rho/Rock signaling pathway and the regulation of placental trophoblast infiltration in preeclampsia / 中国医师杂志

ABSTRACT

Preeclampsia is caused by the dysfunction of placental trophoblast infiltration.The trophoblast immersed in endometrial layer shallow (only up to decidua layer),concurrently resulted in uterine vascular remodeling disorder,and cause placental tissue ischemia,hypoxia,and a series of clinical manifestations of preeclampsia.Rho is a guanosine triphosphate-binding protein whose downstream molecule is Rho-associated coiled-coil forming protein kinase (Rock).Recent studies suggest that Rho/Rock signaling pathway,by regulating the polymerization state of intracellular microfilament skeleton,affects the behavior and function of cells,such as cell adhesion,migration,cell contraction,infiltration and transformation of cancer cells,etc.Thus is involved in the pathogenesis of many diseases.This article summarized the progress of research in the influence of trophoblast infiltration capacity,activation,regulation and the relationship with pregnancy of Rho/Rock signaling pathway,to provide reference for clinical research.