Prognostic values of NLR and platelet count before and after chemotherapy in patients with advanced non-small cell lung cancer / 国际肿瘤学杂志

ABSTRACT

Objective To investigate the prognostic values of neutrophil to lymphocyte ratio (NLR) and platelet count before and after chemotherapy in patients with advanced non-small cell lung cancer (NSCLC).Methods From October 2011 to December 2012,70 patients with advanced NSCLC in Anyang Cancer Hospital of Henan Province were collected.NLR and platelet were calculated from complete blood counts in laboratory test before and after 2 cycles of chemotherapy.The patients were divided into two groups according to the NLR and platelet countlow NLR group (≤3.43)and high NLR group (>3.43);normal group (100 ×109 /L <platelet count <300 ×109 /L)and high platelet group (≥300 ×109 /L).According to the changes of NLR before and after chemotherapy,we divided the patients into 3 groups①low NLR group before chemotherapy;②high NLR group before but declined to low NLR group after chemotherapy;③high NLR group before and after chemotherapy.According to the changes of platelet count before and after chemo-therapy,we divided the patients into 3 groups①normal platelet count group before chemotherapy;②high platelet count group before but declined to normal group after chemotherapy;③high platelet count group before and after chemotherapy.The clinicopathological characteristics and long-term survivals between the subgroups were compared.Results The median survival time of the low and high NLR group were 16.0 and 12.5 months,respectively,with a significant difference (χ2 =3.654,P =0.041).The median survival time of the normal and high platelet group were 14.3 and 10.0 months,respectively,with a significant difference (χ2 =5.358,P =0.021).The median survival times of patients in the 3 groups according to the changes of NLR before and after chemotherapy were 14.5,12.1 and 9.0 months respectively,with statistically significant (χ2 =7.701,P =0.021).The median survival times of patients in the 3 groups according to the changes of platelet count before and after chemotherapy were 14.3,13.1 and 10.4 months,with statistically significant (χ2 =12.775,P =0.002).COX multivariate analysis showed that NLR (RR =1.467,95% CI1.014-2.124,χ2 =4.130,P =0.042),platelet (RR =1.631,95%CI1.108-2.402,χ2 =6.137,P =0.013)and TNMstage(RR =1.380,95%CI 为 1.052-1.809,χ2 =5.420,P =0.020)were independent prognostic factors of patients with advanced NSCLC.Conclusion NLR and platelet before chemotherapy are independent risk factors for patients with advanced NSCLC.Patients with elevated NLR and platelet have shorter survival time.