Preparation Technology Optimization of Salicylic Acid Drop Pills / 中国药师
China Pharmacist
;
(12): 1200-1202, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-494903
ABSTRACT
Objective:
To study the influencing factors in the preparation of salicylic acid dropping pills , and determine the opti-mum preparation process .Methods:
The environmental factors , heating temperature , matrix ratio and preparation steps of salicylic acid drop pills were observed .With pill weight difference , dissolution time and appearance quality as the indices , an orthogonal test was adopted to optimize the preparation process .Results:
Salicylic acid and the matrix should be separately heated to prevent red ox-ide.The optimized preparation process of drop pills was as followsthe ratio of PEG 400 and PEG 6000 was 1∶5, the temperature of drug solution was 50℃, the dropping distance was 8 cm and the dropping rate was 70 drops per minute .Conclusion:
The preparation process is simple and practicable .The pill weight difference , dissolution time and appearance quality all meet the quality require-ments.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2016
Tipo de documento:
Artigo
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