Prognostic value of plasma D-dimer level in patients with advanced non-small-cell lung cancer and its rela-tion with pulmonary embolism / 医学研究生学报

ABSTRACT

Objective Non small cell lung cancer( NSCLC) is a common tumor and the blood of NSCLC patients is generally in a state of high coagulation.However, as a predictor of coagulation, few study has been done on the role of D-dimer level in lung cancer.This article aimed to analyze the prognostic value of plasma D-dimer level in patients with advanced NSCLC and its relation with pulmonary embolism Methods The study collected patients with lung cancer treated in Tianjin Chest Hospital from January 1, 2013 to October 31, 2015.The serum levels of D-dimer were measured by enzyme-linked immunosorbent assay.Based on different lev-els, the patients were divided into high expression group and normal expression group.The relationship between D-dimer level and the prognosis of lung cancer patients were analyzed by Kaplan-Meier method and Log-rank test univariate analysis.T test was used to ana-lyze the difference of D-dimer between patients with and without pulmonary embolism. Results In all the enrolled subjects,103 ca-ses (73.75%) of plasma D-dimer were normal, while 37 patients (26.25%) were elevated.Survival analysis showed that the patho-logical status, tumor size and D-dimer were independent prognostic factors; and the D-dimer in patients with pulmonary embolism was 5.37 ±1.23 μg/mL, while the patients without pulmonary embolism was 0.43 ±0.73μg/mL, D-dimer in patients with pulmonary embol-ism was high than the patients without pulmonary embolism, showing significant difference (P<0.05). Conclusion Plasma D-dimer is an independent prognostic factor for the prognosis of lung cancer, which is obviously higher in patients with lung cancer and pulmonary embolism than in patients without pulmonary embolism.