Relationship of Traditional Chinese Medical Syndromes of Type 2 Diabetic Nephropathy with Inflammatory Factors / 广州中医药大学学报

ABSTRACT

Objective To explore the relationship between traditional Chinese medicine(TCM) syndrome types of diabetic nephropathy(DN) patients and inflammatory factors, thus to supply evidence for syndrome differentiation, clinical treatment, illness evaluation and prognosis of DN patients. Methods The study was carried out in 120 cases of DN patients, and the patients were differentiated into TCM syndromes according to the clinical manifestations. Blood and urine samples were detected with enzyme-linked immunosorbent assay (ELISA). The correlation of syndrome types with blood and urine tumour necrosis factor-like weak inducer of apoptosis (TWEAK), interleukin-1β(IL-1β) and IL-10 was analyzed, and the detection results were compared to 30 healthy volunteers. Results (1) Compared with the healthy control, abnormal blood and urine TWEAK content and abnormal blood IL-1β were shown in DN patients at the stages of non-albuminuria, small-amount albuminuria, large-amount albuminuria, and renal insufficiency(P<0.05); blood IL-10 content was increased in DN patients without albuminuria(P<0.05).(2) DN patients with yin-deficiency and dryness-heat had higher blood and urine TWEAK contents than DN patients with other syndrome types (P<0.05). The blood TWEAK content was in decreasing sequence in the syndrome types of yin-deficiency and dryness-heat, Qi-yin deficiency, spleen-kidney Qi deficiency, yin-yang deficiency; the urine TWEAK content was in decreasing sequence in the syndrome types of yin-deficiency and dryness-heat, Qi-yin deficiency, spleen-kidney Qi deficiency, yin-yang deficiency(P<0.05). DN patients with damp-heat syndrome had the highest blood IL-1βcontent (P < 0.05), and yin-deficiency and dryness-heat had the lowest IL-1β content (P < 0.05). DN patients with yin-deficiency and dryness-heat had higher blood IL-10 content (P<0.05), and the blood IL-10 content was in decreasing sequence in the syndrome types of yin-deficiency and dryness-heat, Qi-yin deficiency, spleen-kidney Qi deficiency, yin-yang deficiency. Conclusion TCM syndrome types of DN patients are correlated with TWEAK, IL-1β and IL-10, and the results will supply evidence for syndrome differentiation, clinical treatment, illness evaluation and prognosis of DN patients .