Your browser doesn't support javascript.
loading
Optimization of Preparation Technology for Compound Pyocutaneous Gels / 医药导报
Herald of Medicine ; (12): 1001-1003, 2016.
Article em Zh | WPRIM | ID: wpr-495993
Biblioteca responsável: WPRO
ABSTRACT
Objective To optimize the matrix prescription and preparation technology of compound pyocutaneous gels. Methods Use the method of L9(34 ) orthogonal test, take the Carbopol-940 quantity, pH, glycerol and ethanol as factors,and take viscosity, pH value, appearance properties, temperature resistance as the comprehensive evaluation index, and compare the effects of stewing, centrifugal and ultrasound methods on removing bubbles in the gel. Ultimately determine the optimum preparation process. Results The best matrix prescription of compound pyocutaneous gels is as follows: carbopol-940 1.4%, 10% sodium hydroxide solution 3.3%,glycerol 2.3%,ethanol 6%;the best way to remove bubbles is centrifugation,with rotation rate at 3 000 r?min-1 for 10 min. Conclusion The selected matrix formulation is simple and feasible, the preparation technology is stable and reliable with good reproducibility, and can be used for the preparation of compound pyocutaneous gel.
Palavras-chave
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Herald of Medicine Ano de publicação: 2016 Tipo de documento: Article
Texto completo: 1 Índice: WPRIM Idioma: Zh Revista: Herald of Medicine Ano de publicação: 2016 Tipo de documento: Article