High mobility group box 1 protein and intracerebral hemorrhage / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 565-568, 2016.
Article
em Zh
| WPRIM
| ID: wpr-496010
Biblioteca responsável:
WPRO
ABSTRACT
High mobility group box l protein (HMGB1) is a highly conserved non-histone DNA binding protein,which is widely distributed in eukaryotic cells.HMGB1 is an important proinflammatory cytokine,involving in various pathological and physiological processes,such as inflammation,neurogenesis and angiogenesis.In the early stage of intracerebral hemorrhage,HMGB1 can induce secondary brain injury,such as inflammatory reaction,neuronal necrosis,and brain edema.However,in the late stage of intracerebral hemorrhage,HMGB1 can promote angiogenesis and neurogenesis,and thus improving neurological function.HMGB1 will become a novel therapeutic target for intracerebral hemorrhage in the future.
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Índice:
WPRIM
Idioma:
Zh
Revista:
International Journal of Cerebrovascular Diseases
Ano de publicação:
2016
Tipo de documento:
Article