Moleculobiological pathogenesis, diagnosis and treatment of epstein-barr virus-associated hemophagocytic lymphohistiocytosis in children / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 430-433, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-496079
ABSTRACT
Epstein-Barr (EB) virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) onset dangerous,rapid progress,the prognosis is poor,with high mortality without treatment.The specific pathogenesis is not entirely clear,it may be related to SH2D1A gene mutation and EBV potential membrane protein 1 (LMP1) concerned.Diagnosis first need to comply with hemophagocytic lymphohistiocytosis (HLH) diagnostic criteria,and there is evidence of EB virus infection,while excluding primary HLH.The preferred treatment in combination with chemotherapy,if the poor effect of chemotherapy,viable hematopoietic stem cell transplantation and monoclonal antibody therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo prognóstico
Idioma:
Chinês
Revista:
International Journal of Pediatrics
Ano de publicação:
2016
Tipo de documento:
Artigo
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