The correlation of PIK3CA gene mutation and the efficacy of anti-HER2 targeted therapy for breast cancer / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 699-702, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-497464
ABSTRACT
It has been shown that the PIK3CA mutation in HER2 positive breast cancer is up to 25%, and thus activates PI3K-Akt signaling pathway,promotes HER2 mediated tumor cell epithelial transformation, alters the intrinsic phenotype of HER2 overexpression breast cancer,and finally leads to resistance to anti HER2 targeted therapy.Some studies have shown that the PIK3CA gene mutation is associated with the efficacy of anti-HER2 targeted therapy.Therefore,real-time monitoring of PIK3CA gene mutation will promote indivi-dualized anti-HER2 targeted therapy.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Oncology
Ano de publicação:
2016
Tipo de documento:
Artigo
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