MicroRNA-146a C ＞ G polymorphism and the risk of ischemic stroke: a meta-analysis / 国际脑血管病杂志

ABSTRACT

Objective To investigate the correlation between MicroRNA-146a (miR-146a) C ＞ G polymorphism and ischemic stroke.Methods The case control studies of the relationship between miR-146a polymorphism and ischemic stroke published before February 2016 were retrieved comprehensively.The Statal2.0 software package was used to conduct the meta-analysis.The odds ratio (OR) and 95％ confidence interval (CI) were used to evaluate the strength of association between the polymorphisms and the risk of ischemic stroke.Results A total of 8 articles were enrolled,including 2 891 patients in the case group and 4 019 in the control group.The selected literature did not have obvious publication bias.In the general population,the dominant model (GG + CG vs.CCOR 1.011,95％ CI 0.863-1.185;P =0.889),recessive model (GG vs.CG + CCOR 0.999,95％ CI 0.761-1.311;P=0.994),heterozygous model (CG vs.CCOR 1.052,95％ CI 0.943-1.173;P =0.368),homozygous model (GG vs.CCOR 1.114,95％ CI 0.819-1.515;P =0.491),and allele model (G vs.COR 1.062,95％ CI0.919-1.227;P=0.413) did not show significant correlation between the miR-146a C ＞ G polymorphism and the risk of ischemic stroke.Subgroup analysis showed that the miR-146a C ＞ G polymorphism was not associated with the onset risks of large artery atherosclerotic and small arterial occlusive stroke.Conclusions According to the literature available,the miR-146a C ＞ G polymorphism may not be significantly associated with the risk of ischemic stroke.