Expression of hypoxia inducible factor-1αand transforming growth factor-β1 in endometrial carcinoma and their clinical significances / 中国综合临床

ABSTRACT

Objective To examine the expressions of hypoxia inducible factor?1α( HIF?1α) and trans?forming growth factor?β1 ( TGFβ1) in patients with endometrial carcinoma,to investigate their clinical signifi?cances. Methods Fifty?four patients with endometrial carcinoma and 20 patients with normal endometrium were selected in Yijishan Hospital of Wannan Medical College from2012 to 2015. Expression of HIF?1αand TGF?β1 were detected by immunohistochemical method respectively,the correlations between HIF?1α,TGF?β1 and clinic pathologic characteristics and prognostic significance were analyzed. Results The positive expression rates of HIF?1αand TGF?β1 were 59. 26%( 32/54) and 64. 81%( 35/54) in endometrial carcinoma respectively,signifi?cantly higher than of expression of patients with normal endometrium ( 5. 00%( 1/20 ) , 0 ( 0 );χ2 =17. 390, 24. 596;P<0. 01). The expressions of HIF?1α were correlated with FIGO stage(χ2=6. 712,P=0. 010),tumor thrombus in pulse tube(χ2=4. 804,P=0. 036),deep myometrial invasion(χ2=6. 484,P=0. 011),and lymph node metastasis(χ2 = 5. 732, P= 0. 017 ) . The expression of TGF?β1 were correlated with FIGO stage (χ2=4. 878,P=0. 027) ,deep myometrial invasion(χ2=4. 060,P=0. 044) and lymph node metastasis(χ2=5. 211, P=0. 022). Expression of HIF?1αwas positively correlated with expression of TGF?β1(r=0. 705,P=0. 000) . Conclusion Increased expressions of HIF?1αand TGF?β1 are all involved in carcinogenesis,progression and metastasis of endometrial carcinoma,which may be considered as a target in endometrial carcinoma therapy.