PINK1 and Parkin to control mitochondria remodeling / 대한해부학회지
Anatomy & Cell Biology
;
: 179-184, 2010.
Artigo
em Inglês
| WPRIM
| ID: wpr-49867
ABSTRACT
Parkinson's disease (PD), one of the most common neurodegenerative diseases, is characterized by movement disorders and a loss of dopaminergic (DA) neurons. PD mainly occurs sporadically, but may also result from genetic mutations in several PD-linked genes. Recently, genetic studies with Drosophila mutants, parkin and PINK1, two common PD-associated genes, demonstrated that Parkin acts downstream of PINK1 in maintaining mitochondrial function and integrity. Further studies revealed that PINK1 translocates Parkin to mitochondria and regulates critical mitochondrial remodeling processes. These findings, which suggest that mitochondrial dysfunction is a prominent cause of PD pathogenesis, provide valuable insights which may aid in the development of effective treatments for PD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Doença de Parkinson
/
Doenças Neurodegenerativas
/
Drosophila
/
Mitocôndrias
/
Transtornos dos Movimentos
/
Neurônios
Idioma:
Inglês
Revista:
Anatomy & Cell Biology
Ano de publicação:
2010
Tipo de documento:
Artigo
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