The expression and clinic significance of CIP2A and HPV16-E7 protein in cervical cancer / 实用肿瘤学杂志

ABSTRACT

Objective To explore the expression and correlation of CIP 2A and HPV16-E7 protein in cervical cancer.Methods The expressions of CIP2A and HPV16-E7 in 50 cases of cervical cancer ,34 cases of CINⅠ,40 cases of CINⅡ,45 cases of CINⅢand 12 cases of normal tissues were assessed by immunohistochemi -cal method.R esults The rate of expressions of CIP2A protein in cancer tissues and CINⅢ were 68%(34/50) and 13.3%(6/45)respectively;The rate of expressions of CIP2A protein in CINⅡ、CINⅠtissues and normal tis-sues were negative.The expressions of CIP2A protein in cancer tissues were stronger than in CIN tissues and nor-mal tissues(P0.05).The expression of CIP2A was positively associated with the expression of HPV16-E7 in cervical cancer(r=0.514,P<0.05).Conclu-sion The expressions of CIP2A and HPV16-E7 are very strong in cervical cancer;CIP2A and HPV16 may play important roles in the carcinogenesis and the development of cervical cancer .