Relationship between intestinal microflora imbalance and nonalcoholic fatty liver disease / 临床肝胆病杂志

ABSTRACT

The intestinal microecosystem is composed of natural microflora,intestinal epithelial cells,and intestinal mucosal immune sys-tem.Nonalcoholic fatty liver disease (NAFLD)is a metabolic stress-induced liver injury associated with insulin resistance and genetic sus-ceptibility.In recent years,there has been increasing evidence showing the involvement of imbalanced intestinal microflora in the pathogene-sis of NAFLD.Overgrowth of intestinal microflora,increased permeability of intestinal mucosa,intestinal endotoxemia,and production of in-flammatory cytokines play important roles in the development of NAFLD.Further studies on the relationship between intestinal microflora im-balance and the pathogenesis of NAFLD may shed light on the treatment and prevention of NAFLD.