Progress and prospect of diagnosis and treatment of hepatic fibrosis by integrated traditional Chinese and Western medicine therapy / 临床肝胆病杂志

ABSTRACT

In recent years,non-invasive methods for assessment of hepatic fibrosis have attracted more and more attention,and the appli-cation of non-invasive diagnostic techniques such as serum markers and transient elastography (FibroScan)for hepatic fibrosis is reviewed. Anti-fibrosis treatments should integrate etiological treatment,anti-inflammatory and liver-protecting therapy,and inhibiting the synthe-sis of extracellular matrix and degrading excessively deposited extracellular matrix.Antiviral treatment is the basis for resisting hepatic fibro-sis due to chronic viral hepatitis.In this aspect,traditional Chinese medicine (TCM)has advantages in inhibiting the synthesis of extracellu-lar matrix and degrading excessively deposited extracellular matrix,because it effects on multiple links,at multiple levels,and against multi-ple targets.So integrated traditional Chinese and Western medicine therapy is a promising treatment strategy.However,the benefit of inte-grative therapy against hepatic fibrosis still needs to be supported by rigorously designed,multicenter,large-sample clinical studies,and the mechanism of anti-fibrosis TCM treatment deserves further studies.