Protein Tyrosine Phosphatase 1B Inhibitors from Plantago asiatica / 中草药·英文版
Chinese Herbal Medicines
; (4): 136-139, 2011.
Article
em Zh
| WPRIM
| ID: wpr-499740
Biblioteca responsável:
WPRO
ABSTRACT
Objective To identify the active compounds for protein tyrosine phosphatase 1B (PTP1B) from the seeds of Plantago asiatica. Methods Bioassay-guided fractionation resulted in the isolation of iridoid glucosides (1-5) with PTP1B inhibitory activity. Results Five compounds were identified as desacetylhookerioside (1), melittoside (2), geniposidic acid (3), 10-O-acetyl-geniposidic acid (4), and alpinoside (5). Conclusion Isolated compounds 3-5 inhibit PTP1B with IC50 values ranged from (16.3 ± 1.1) to (19.8 ± 1.2) μmol/L.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Herbal Medicines
Ano de publicação:
2011
Tipo de documento:
Article